In reply to Christina Katsiadakis's post on Sun 17 Apr 2011 :
I like to start interviewing them with questions I don't really care about, and allow them to drive the interview. I never stop them and tell them to rephrase, and I will allow the interview to get as off topic as they want it to be. I use a very light hand as I guide them toward the questions and answers I care about, that way by the time we get there they are comfortable and feel as if they brought up the topic themselves. That way they don't feel like they're in the hot-seat.
Note: some people will never be very comfortable in front of a camera, some will automatically be super comfortable. All these tips everyone is giving need to be tailored to each specific person you speak with.